Ruiz knocked down Ortiz three times on the way to a victory by unanimous decision in Los Angeles.
Wilder – who was ringside to watch Ruiz’s win – meanwhile returns to the ring next month in a separate WBC eliminator against Robert Helenius.
Ruiz has already shown his willingness to go ahead with the fight against the 36-year-old if he wins, calling on Premier Boxing Champions boss Al Haymon to get a deal done.
‘God willing he [Wilder] wins against Robert in October,’ Ruiz said after his victory.
‘I and him are in the same organization, I want to thank Al Haymon, he can make this fight happen and let’s do it, let’s get it on.’
Ruiz pulled off one of the bigger upsets in recent heavyweight history when he took Anthony Joshua’s three championship belts in 2019, only to lose them back to his British opponent six months later.
Ruiz had fought just once since, but he got his head down again in training with hopes of getting another shot at the belts.
‘I do not want to be waiting,’ Ruiz said. ‘I want to fight at least three or four times a year. I’m hungry, man. I want to be a champion again.
‘It was very difficult,’ Ruiz added of the fight. ‘I was waiting for him to load up, and countering him when he did. It was a blessing we were able to be successful.’
Wilder has not fought since losing his trilogy fight against WBC champion Fury in October last year.
